Title : Association of right ventricular strain with left ventricular subclinical dysfunction in type 2 diabetes mellitus patients
Abstract:
Introduction: Type 2 Diabetes Mellitus is one of the important factors in the development of heart failure, especially HF with preserved ejection fraction.
Aim: To investigate the presence of subclinical RV and LV systolic dysfunction in asymptomatic patients with T2DM and preserved LVEF without coronary artery disease and the association between LV longitudinal myocardial function and RV systolic function in such patients.
Objectives: To assess the right ventricular and LV subclinical dysfunction in patients with diabetes mellitus.
Methods: Asymptomatic (> 18 years) patients with T2DM and preserved LVEF with no coronary artery disease with healthy age-sex matched control .Baseline ECG and TMT was done in all the cases. Detailed 2D echocardiography was done. LV and RV strain were analysed.
Result: We studied 50 T2DM patients with preserved LVEF and 50 age, sex, and LVEF-matched healthy volunteers. Mean age of cases was 52.1+/-11.9 years and control was 50.1+/-14.2 years. RV free wall strain in T2DM patients was significantly lower than that in normal controls (12.12±5.29 vs. 20.10±5.07 %; P < 0.0001). LV GLS in T2DM patients was significantly lower than that in normal controls (16.31±2.97vs. 19.04±3.61%; P < 0.0001).
Conclusion: RV subclinical systolic dysfunction was observed in asymptomatic patients with T2DM and preserved LVEF without coronary artery disease and was associated with LV longitudinal myocardial dysfunction.
